TABLE 1.
Inhibition of the NA activity of avian influenza A viruses by RWJ-270201, zanamivir, and oseltamivir carboxylate
| NA subtype | Virusb | Mean IC50 ± SE (nM)a
|
||
|---|---|---|---|---|
| RWJ-270201 | Zanamivir | Oseltamivir carboxylate | ||
| N1 | A/teal/Hong Kong/W312/97 (H6N1) | 2.6 ± 0.4 | 19.7 ± 4.2 | 36.1 ± 8.3 |
| A/duck/Alberta/35/76 (H1N1) | 3.4 ± 1.0 | 5.8 ± 2.1 | 53.2 ± 10.3 | |
| N2 | A/chicken/NY/13307-3/95 (H7N2) | 2.7 ± 1.1 | 7.4 ± 0.4 | 2.7 ± 1.1 |
| A/turkey/Wisconsin/66 (H9N2) | 2.0 ± 0.6 | 4.7 ± 0.7 | 1.9 ± 0.2 | |
| N3 | A/duck/Singapore/3/97 (H5N3) | 3.8 ± 1.4 | 4.9 ± 0.8 | 2.9 ± 0.7 |
| A/duck/Germany/1215/73 (H2N3) | 3.1 ± 0.6 | 5.9 ± 0 | 3.3 ± 1.2 | |
| N4 | A/red knot/DE/254/94 (H8N4) | 2.3 ± 0.6 | 4.5 ± 1.3 | 47.0 ± 0 |
| A/turkey/Ontario/6118/68 (H8N4) | 3.2 ± 0.6 | 2.2 ± 0.9 | 5.5 ± 2.4 | |
| N5 | A/mallard duck/Astrakhan/263/82 (H14N5) | 2.7 ± 1.1 | 13.6 ± 1.9 | 36.8 ± 5.2 |
| A/shearwater/Australia/1/72 (H6N5) | 1.2 ± 0.1 | 29.7 ± 1.6 | 33.2 ± 1.9 | |
| N6 | A/shorebird/DE/224/97 (H13N6) | 1.3 ± 0.8 | 7.2 ± 0.6 | 4.9 ± 1.0 |
| A/duck/Czechoslovakia/56 (H4N6) | 3.1 ± 0.5 | 3.4 ± 2.1 | 3.2 ± 0.1 | |
| N7 | A/chicken/Jena/1816/87 (H7N7) | 1.5 ± 0.3 | 5.9 ± 1.5 | 4.4 ± 0.9 |
| A/duck/Germany/“N”/49 (H10N7) | 4.3 ± 1.8 | 7.2 ± 0.6 | 8.2 ± 2.1 | |
| N8 | A/duck/Hong Kong/Y264/97 (H4N8) | 1.2 ± 0.3 | 30.1 ± 2.9 | 69.2 ± 3.4 |
| A/quail/Italy/1117/65 (H10N8) | 1.1 ± 0.3 | 5.3 ± 0.6 | 29.7 ± 1.4 | |
| N9 | A/duck/Hong Kong/P50/97 (H11N9) | 0.9 ± 0.1 | 11.5 ± 4.6 | 17.7 ± 4.9 |
| A/duck/Memphis/546/74 (H11N9) | 1.6 ± 0.1 | 10.4 ± 4.6 | 9.5 ± 1.6 | |
| Range (N1–N9) | 0.9–4.3 | 2.2–30.1 | 1.9–69.2 | |
a
MUN (final concentration of 100 μM) was used as the substrate. Values are means ± SEs of at least three independent determinations.
b
The second strain in each pair is the reference strain of influenza A virus used for the antigenic subtyping of the NA of the new influenza isolates.