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. 2022 May 5;12:7341. doi: 10.1038/s41598-022-11358-7

Table 1.

Main baseline characteristics by gender.

Total Women Men
n (%) 1158 (100) 637 (55) 521 (45)
Age in years, mean (SD) 84.4 (5.6) 84.1 (5.6) 84.8 (5.7)
Education (CASMIN-short), n (%)
 Low 686 (59) 417 (66) 269 (52)
 Middle 235 (20) 148 (23) 87 (17)
 High 232 (20) 71 (11) 161 (31)
 Unknown 5 (0.4) 1 (0.2) 4 (0.8)
Smoking, n (%)
 Never 622 (54) 458 (72) 164 (32)
 Ever 532 (46) 176 (28) 356 (68)
 Unknown 4 (0.3) 3 (0.5) 1 (0.2)
Self-rated health, n (%)
 Excellent / good 521 (45) 267 (42) 254 (49)
 Moderate / poor / very poor 634 (55) 368 (58) 266 (51)
 Unknown 3 (0.3) 2 (0.3) 1 (0.2)
Living alone, n (%) 552 (48) 393 (62) 159 (31)
 Unknown 38 (3) 25 (4) 13 (2)
BMI in kg/m2, n (%)
  < 25 377 (33) 225 (35) 152 (29)
 25–29.9 509 (44) 251 (39) 258 (50)
  ≥ 30 255 (22) 154 (24) 101 (19)
 Unknown 17 (1) 7 (1) 10 (2)
Polypharmacy, n (%) 848 (73) 470 (74) 378 (73)
 Unknown 1 (0.1) 0 (0) 1 (0.2)
Hospitalization, n (%)
 0 489 (42) 284 (45) 205 (39)
 1–2 448 (39) 230 (36) 218 (42)
  ≥ 3 221 (19) 123 (19) 98 (19)
CCI, median (IQR) 10 (7–12) 9 (7–12) 10 (8–13)
Cognitive impairment, n (%) 95 (8) 55 (9) 40 (8)
 Unknown 68 (6) 32 (5) 36 (7)
Hypertension, n (%) 958 (83) 533 (84) 425 (82)
 Unknown 2 (0.2) 1 (0.2) 1 (0.2)
Stroke, n (%) 156 (14) 75 (12) 81 (16)
Congestive Heart failure, n (%) 756 (65) 390 (61) 366 (70)
Diabetes mellitus, n (%) 341 (29) 171 (27) 170 (33)
 Unknown 15 (1) 8 (1) 7 (1)
Cancer, n (%) 315 (27) 134 (21) 181 (35)
Osteoarthritis, n (%) 935 (81) 558 (88) 377 (72)
COPD, n (%) 450 (39) 254 (40) 196 (38)
eGFRBIS2 < 60 ml/min/1.73m2, n (%) 847 (73) 468 (74) 379 (73)
 Unknown 34 (3) 22 (3) 12 (2)
ACR ≥ 30 mg/g, n (%) 306 (26) 137 (22) 169 (32)
 Unknown 77 (7) 49 (8) 28 (5)
Frailty status, n (%)
 Robust 225 (19) 115 (18) 110 (21)
 Prefrail 532 (46) 282 (44) 250 (48)
 Frail 401 (35) 240 (38) 161 (31)
Frailty transition after 2.1 years, n (%)
 Improvement 160 (14) 101 (16) 59 (11)
 No change 547 (47) 304 (48) 243 (47)
 Worsening 322 (28) 162 (25) 160 (31)
 Unknown 129 (11) 70 (11) 59 (11)

SD standard deviation, BMI body mass index, CCI Charlson Comorbidity Index, COPD chronic obstructive lung disease, eGFR estimated glomerular filtration rate, ACR albumin to creatinine ratio.