Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 May 5;12:7324. doi: 10.1038/s41598-022-11048-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

EB-FPDK11 and EB-AMDK19 enhance skin barrier proteins in AD-like lesion in NC/Nga mice. (A) The first lane: H&E staining of dorsal skin lesions. The yellow arrowheads indicate hyperplasia, and the yellow arrows indicate hyperkeratosis. The 2nd–4th lane: Immunohistochemical staining of filaggrin, ZO-1, claudin-1, and TSLP, respectively in dorsal skin lesions in DNCB-induced NC/Nga mice. Dark brown regions (the red arrows) indicate positively stained cells. Scale bar, 50 µm. (B, C) The graphs represented as (B) Hyperkeratosis (C) Hyperplasia, histological grades were scored as follows: 0, normal thickness; 1, two times normal thickness; 2, three times normal thickness; 3, four times normal thickness; or 4, greater than four times normal thickness. Data are presented as mean ± SEM of changes in values. *P < 0.05; **P < 0.01; ***P < 0.001; *versus normal group; ^#versus DNCB group; ^$versus DEX group.