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. 2022 May 5;13:2476. doi: 10.1038/s41467-022-30162-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Neutralizing antibody responses of HCWs (n = 59) were analyzed with a microneutralization test against SARS-CoV-2 isolates representing D614G, Delta and Omicron BA.1 variants. Serum samples were collected before the first vaccine dose and three weeks after the second and the third vaccine dose. Additionally, follow-up serum samples were collected 3, 6, and 8 months after the second vaccine dose. A vaccinee with a PCR-confirmed SARS-CoV-2 infection after vaccination is marked with red dots. b Neutralization titers against D614G, Delta, and Omicron BA.1 variants after the second and third vaccine doses were compared. Geometric mean, shown as a line with geometric SD, is indicated above the figure with the percentage of positive samples when neutralization titer ≥20 is considered positive. Differences between neutralization titers were analyzed with two-sided Wilcoxon signed-rank test and p-values <0.05 were considered statistically significant. P-values <0.0001 are marked with ****. c Amino acid changes in Delta and Omicron BA.1 compared to Wuhan Hu-1 sequence are shown in trimeric SARS-CoV-2 spike protein structure (PDB: 6VXX). Substitutions are highlighted with magenta and deletions with orange. Changes located in the receptor-binding domain are bolded.