TABLE 3.
Genotypic analysis of RT of tenofovir DF-treated subjects with baseline nucleoside-associated RT mutations
| Tenofovir DF dose (mg) and subject code | Prior antiretroviral therapya | Nucleoside-associated RT mutation(s)b
|
|
|---|---|---|---|
| Day 0 | Day 35 | ||
| 75 | |||
| A | AZT, 3TC, d4T, ddI, IDV | M41L, T215Y | M41L, T215Y |
| B | AZT, 3TC | M184V | M184V |
| 150 | |||
| C | AZT, 3TC | M184V | None |
| D | AZT, 3TC, d4T, IDV | M184V/M | None |
| E | AZT, 3TC, d4T | M184V | M184V |
| F | AZT, 3TC, SQV, IDV | M184V/M | M184V |
| G | AZT, 3TC, d4T, SQV | M184V | M184V |
| 600 | |||
| H | AZT, 3TC, d4T, ddC | M41L/M, M184V/M, T215Y | M41L, T215Y |
| I | AZT, 3TC, d4T, 3TC, ABC, SQV, NFV, RTV | M41L/M, T69A/T, M184V/M, T215Y/T | M41L/M, T215Y/T |
a
ddI, didanosine; ddC, zalcitabine; ABC, abacavir; IDV, indinavir; SQV, saquinavir, NFV, nelfinavir; RTV, ritonavir.
b
Nucleoside-associated RT codons are M41, K65, D67, T69, K70, L74, V75, Q151, M184, L210, T215, and K219.