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. 2022 May 5;13:2460. doi: 10.1038/s41467-022-29978-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Design of antigenic drift experiment using variants of the NIP hapten. b NIP-specific and TNP-specific IgG1 antibody titer and affinity in ACKR4^+/− and ACKR4^−/− mice. Merged data from 4 independent experiments with five mice each (total n = 20). Boxes show medians and 50% range, whiskers: 5–95%. Symbols represent individual mice. Two-tailed Mann-Whitney test, ****p < 0.0001.