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. 2022 May 5;13:2469. doi: 10.1038/s41467-022-30196-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a–c The ROC-AUC curves derived from pan-essential and nonessential paralog pairs across distinct libraries in (a) IPC298, (b) MELJUSO, and (c) PK1. AUC values are indicated in parentheses. d Correlation between the average LFC of dual knockouts with inverted positions of sgRNAs in IPC298. Pearson’s correlation coefficient is indicated (r value) in black. Percent of pan-essential paralog pairs with LFC less than −1 for both sgRNAs in positions are indicated in red. Pan-essential paralog pairs are annotated by red dots. Source data are provided in the Source Data File.