TABLE 1.
WHV DNA reduction versus baseline
| Adefovir dipivoxil dosage (mg/kg/day) and animala | Baseline DNA | Fold reduction in DNAb
|
|||
|---|---|---|---|---|---|
| Wk 2 | Wk 4 | Wk 12 | Wk 18 | ||
| 15 mg/kg/day | |||||
| HC297 | 83.3 | 5.1 | 416.7 | 39.7 | −2.7 |
| HC298 | 75.5 | 15.4 | 8.5 | 228.7 | −2.0 |
| HC299 | 135.7 | 393.2 | 33.4 | >2,228.1 | 1.2 |
| HC302 | 165.3 | 118.1 | 4.2 | 570.0 | 1.5 |
| HC303 | 101.1 | 16.6 | 51.0 | 40.4 | 2.6 |
| HC307 | 195.6 | 93.1 | >3,259.5 | >3,259.5 | 2.0 |
| Mean | 118.3 | 42.1cd | >66.0c | >339.0c | 1.1 |
| SE | 18.4 | 27.8 | >67.0 | >264.2 | 0.3 |
| 5 mg/kg/day | |||||
| HC197 | 15.1 | 7.2 | 50.2 | 251.0 | −1.8 |
| HC199 | 34.0 | 17.0 | 20.0 | >566.0 | −3.0 |
| HC247 | 22.8 | 67.2 | >380.6 | >380.6 | −6.5 |
| HC304 | 41.8 | 5.0 | 4.3 | 43.1 | −1.4 |
| HC305 | 56.7 | −1.7 | 2.0 | 2.1 | −1.9 |
| HC312 | 141.2 | 2.5 | 7.1 | 1.7 | 1.0 |
| Mean | 39.7 | 6.3e | >16.9e | >45.0c | −2.1 |
| SE | 12.6 | 4.1 | >13.1 | >48.0 | 0.1 |
| Control | |||||
| HC212 | 11.7 | −1.6 | −2.1 | −9.4 | −9.3 |
| HC268 | 22.4 | −2.1 | −2.1 | −2.5 | −3.8 |
| HC271 | 8.6 | −3.0 | −4.2 | −2.1 | −1.1 |
| HC296 | 34.6 | −1.1 | −1.5 | −1.6 | −1.6 |
| HC309 | 44.8 | 1.0 | 2.2 | −1.1 | 1.6 |
| Mean | 20.3 | −1.6 | −1.6 | −2.4 | −2.1 |
| SE | 6.4 | 0.1 | 0.2 | 0.2 | 0.2 |
a
Means are geometric means; SE, geometric standard error estimate.
b
Analysis of variance with pairwise contrasts was performed to compare log fold reductions among groups. Groups were significantly different from the control if P was ≤0.05. Negative numbers indicate an increase.
c
Significantly different from control, P ≤ 0.01.
d
Significantly different from 5 mg/kg/day, 0.01 < P ≤ 0.05.
e
Significantly different from control, 0.01 < P ≤ 0.05.