Figure 6.
Quantification of duty cycle and ATP/ADP normalized over the range of values of glucose for the integrated oscillator model (A) and the phantom bursting model (B). The normalized ATP/ADP value < ATP/ADP > n increases with increases in glucose concentration while the model cell is quiescent, but once the cell is busting, < ATP/ADP > n is invariant to changes in glucose concentration. When the cell enters a tonic spiking state, there is a small decline in <ATP/ADP > n due to ATP hydrolysis by Ca2+ pumps. To see this figure in color, go online.