Hazard ratio (95% confidence interval) of incident kidney failure needing replacement therapy as a function of each biomarker in models adjusted for age, race, sex, education, body mass index, systolic blood pressure, use of anti-hypertensive mediations, smoking status, coronary heart disease, stroke, urine albumin to creatinine ratio, and estimated glomerular filtration rate. All biomarkers were analyzed on a continuous scale (per two-fold higher concentration).