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In vitro PK profiles simulated in the bioreactor with concentrations in broth (free concentrations) equal to free (A) and total (B) GM 237354 in vivo concentrations in serum following administration of 2.5, 10, and 40 mg/kg every 8 h. ·⃟, observed values in the central compartment of the bioreactor when simulating 40 mg/kg every 8 h.
