FIG. 7.

Relationship between in vivo and in vitro E_OBSs over the whole experimental period as summarized by AUKTC_{OBS, IN VITRO} for broth burden versus AUSTC_{OBS, IN VIVO} for survival. Symbols: ○, total in vivo serum GM 237354 concentrations reproduced in vitro; +, free in vivo serum GM 237354 concentrations reproduced in vitro. Linear regressions were AUKTC_{OBS, IN VITRO} = 378 − 0.058 · AUSTC_{OBS, IN VIVO} for free concentrations simulated in vitro (R² = 0.946) and AUKTC_{OBS, IN VITRO} = 340 to 0.064 · AUSTC_{OBS, IN VIVO} for total concentrations (R² = 0.655) simulated in vitro.