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. 2019 Oct 2;9(54):31217–31223. doi: 10.1039/c9ra07604b

Variation of the Grignard reagents (conditions A and B).

graphic file with name c9ra07604b-u30.jpg
Entry RMgBr R′ Yielda [%]
A B
1 MeMgBr Ph 68
2 graphic file with name c9ra07604b-u31.jpg Ph 0 0
3 graphic file with name c9ra07604b-u32.jpg Ph 68
4 H 76
5 graphic file with name c9ra07604b-u33.jpg Ph 65
6 H 64
7 graphic file with name c9ra07604b-u34.jpg Ph 75
8 H 71
9 PhMgBr Ph 11 64
10 H 17 65
11 graphic file with name c9ra07604b-u35.jpg Ph 77
12 H 22 82
13 nC6H13 <5 <5
14 graphic file with name c9ra07604b-u36.jpg Ph 42
15 graphic file with name c9ra07604b-u37.jpg Ph 0 0
a

Isolated yields; E/Z of products >50/1.