Variation of the Grignard reagents (conditions A and B).
| ||||
|---|---|---|---|---|
| Entry | RMgBr | R′ | Yielda [%] | |
| A | B | |||
| 1 | MeMgBr | Ph | — | 68 |
| 2 |
|
Ph | 0 | 0 |
| 3 |
|
Ph | — | 68 |
| 4 | H | 76 | — | |
| 5 |
|
Ph | — | 65 |
| 6 | H | — | 64 | |
| 7 |
|
Ph | — | 75 |
| 8 | H | — | 71 | |
| 9 | PhMgBr | Ph | 11 | 64 |
| 10 | H | 17 | 65 | |
| 11 |
|
Ph | — | 77 |
| 12 | H | 22 | 82 | |
| 13 | nC6H13 | <5 | <5 | |
| 14 |
|
Ph | — | 42 |
| 15 |
|
Ph | 0 | 0 |
Isolated yields; E/Z of products >50/1.