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. 2022 Apr 22;13:868892. doi: 10.3389/fimmu.2022.868892

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Copyright © 2022 Zhao, Yao, Chen, He, Xie, Zhang, Lin, Chen, Xie and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Global m⁶A modification changes in the normal livers and ALV-J induced tumor livers. (A) Venn diagram of m⁶A methylation sites identified in mRNAs from two groups. (B) The Volcano plot showed the identification of significant hyper- and hypomethylated m⁶A peaks. (C, D) GO enrichment analysis of biological processes involved in hypermethylated (C) and hypomethylated (D) m⁶A genes in ALV-J infected positive group compared with negative group. (E, F) Pathway analysis of hypermethylated (E) and hypomethylated (F) m⁶A genes in mRNAs of ALV-J infected positive group compared to negative group. Negative represents chickens without ALV-J infection (normal livers); Positive represents chickens with ALV-J infection (tumor livers).