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. 2022 Apr 22;13:825075. doi: 10.3389/fimmu.2022.825075

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Copyright © 2022 Cornish, McDonnell and Williams

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Coexistence of chronic histiocytic intervillositis (CHI) with SARS-CoV-2 infection in a placenta from a late miscarriage at 20 weeks’ gestation. (A) Immunohistochemical staining demonstrates CD68+ histiocytes (brown) in the intervillous space. (B) Positive expression of SARS-CoV-2 nucleocapsid protein (brown) by immunohistochemistry within the syncytiotrophoblast membrane of the same placenta. (A), x20. (B), x4.