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. 2022 Apr 22;9:831260. doi: 10.3389/fmed.2022.831260

Table 2.

Associations of three aging measures with mortality.

No. of death (%) Model 1 Model 2 Model 3
HR (95% CI) p HR (95% CI) p HR (95% CI) p
TL.Accel
Short 301 (20.46) Ref Ref Ref
Normal 362 (20.36) 0.99 (0.85–1.15) 0.868 1.00 (0.86–1.17) 0.992 0.97 (0.82–1.14) 0.711
PA.Accel
Younger 291 (16.04) Ref Ref Ref
Older 372 (25.92) 1.79 (1.54–2.09) <0.001 1.85 (1.58–2.16) <0.001 1.67 (1.41–1.98) <0.001
FI.Accel
Robust 321 (17.19) Ref Ref Ref
Frail 342 (24.75) 1.52 (1.31–1.77) <0.001 1.62 (1.38–1.88) <0.001 1.59 (1.35–1.87) <0.001
PC1
Younger 313 (16.60) Ref Ref Ref
Older 350 (25.68) 1.80 (1.54–2.11) <0.001 1.85 (1.58–2.17) <0.001 1.79 (1.51–2.12) <0.001

HR, hazard ratio; TL.Accel, PA.Accel, and FI.Accel represent residuals from linear models when regressing telomere length, Phenotypic age, and frailty index on chronological age, respectively; PC1, the first principal component of PA.Accel and FI.Accel through the principal component analysis.

Model 1 was a crude model; model 2 adjusted for chronological age and gender; model 3 further adjusted for ethnicity, education level, body mass index, smoking status, binge drinking status, alcohol consumption, leisure time physical activity level, and health eating index based on model 2. The bold values represent that the tests were statistically significant with two-tailed p < 0.05.