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. 2022 Apr 22;16:848730. doi: 10.3389/fnins.2022.848730

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Copyright © 2022 Thapaliya, Marshall-Gradisnik, Staines, Su and Barnden.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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For ME/CFS and HC, significant clusters from interaction-with-group regressions for 2 clinical regressors (“Fatigue” and “HRV”). The volume and thickness cluster of the post central gyrus and inferior parietal was observed in the left hemisphere when regressed with “Fatigue” (left side). The thickness cluster of the superior frontal gyrus was detected at the left hemisphere when regressed with “HRV” (right side). The volume is represented with filled blue color whereas thickness is represented by unfilled green color. Significant volume and thickness clusters were overlaid on the inflated brain (left and right hemisphere) available in the FreeSurfer.