TABLE 2.
Activity of ciprofloxacin, gatifloxacin, and AM-1121 against genetically defined strains of S. aureus
| Strain | Relevant genotype | MICs (μg/ml) of:
|
||
|---|---|---|---|---|
| Ciprofloxacin | Gatifloxacin | AM-1121 | ||
| ISP794 | Wild type (parent) | 0.125–0.25 | 0.064–0.125 | 0.125–0.25 |
| MT5 | gyrB142 | 0.25 | 0.125 | 0.25 |
| SS1 | gyrA (S84L) | 0.25 | 0.125 | 0.25 |
| MT5224c2 | grlA (A116P) | 1.0 | 0.25 | 1.0 |
| MT5224c3 | grlA (A116E) | 1.0 | 0.5 | 1.0 |
| MT5224c4 | grlA (S80F) | 1.0 | 0.25 | 1.0 |
| MT5224c9 | grlB (N470D) | 1.0 | 0.25 | 1.0 |
| MT23142 | flqB (NorA overexpression) | 1.0 | 0.25 | 1.0 |
| MT52184 | gyrB142 grlA (A116P) | 4.0 | 1.0 | 4.0 |
| EN1252a | grlA (S80F) gyrA (S84L) | 32 | 4.0 | 32 |
| MT1222 | grlA (A116E) gyrA (S84L) flqB, other | 32 | 4.0 | 32 |
| RN4220 | 8325-4, r−, parent | 0.5 | 0.25 | 0.5 |
| EN6 | gyrA (S84L) | 0.5 | 0.25 | 0.5 |
| EN14 | grlB (N470D) gyrA | 4.0 | 1.0 | 4.0 |
| EN20 | grlA (S80F) | 4.0 | 0.5 | 2.0 |
| EN9 | grlA (S80F) gyrA (S84L) | 16–32 | 4.0 | 32 |