TABLE 3.
Frequency of selection of resistant mutantsa
| Strain | Selecting drug concn expressed as:
|
Frequency of mutation for:
|
|||
|---|---|---|---|---|---|
| μg/ml | Factor of MIC (CIP/GAT/AM-1121) | CIP | GAT | AM-1121 | |
| ISP794 | 0.25 | 1/2/1 | ND | 1.0 × 10−6–7.3 × 10−8 | ND |
| 0.5 | 2/4/2 | 1.5 × 10−5–2.8 × 10−6 | 2.8 × 10−9–<4.5 × 10−11 | 1.8 × 10−5–4.5 × 10−6 | |
| 1.0 | 4/8/4 | 3.0 × 10−9–6.1 × 10−8 | <2.8 × 10−9–<4.5 × 10−11 | 4.3 × 10−8 | |
| 2.0 | 8/16/8 | 2.8 × 10−9–<4.5 × 10−11 | ND | <4.8 × 10−10–<5.6 × 10−10 | |
a
Abbreviations: CIP, ciprofloxacin; GAT, gatifloxacin. ND, not determined.