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. 2022 Jan 4;30(2):150–161. doi: 10.1016/j.jsps.2021.12.013

Fig. 7.

Fig. 7

Effect of MLK on histopathological alterations in kidney sections stained with H&E (x400) from GM-treated rats. A & B) Control and MLK groups, respectively showing normal glomeruli (G) with normal Bowman’s spaces (BS), normal proximal tubules (P) with preserved brush borders (black arrow), normal distal tubules (D), and normal interstitium (yellow arrow), C) GM single-dose (100 mg/kg) group showing normal glomerulus (G) and Bowman’s space (BS), scattered proximal tubules (P) with edematous (blue arrows) apoptotic epithelial lining (red arrows). D) GM single-dose (120 mg/kg) group showing normal glomerulus (G) and Bowman’s space (BS), scattered completely necrotic proximal tubules (black arrow) and others with complete loss of brush borders (blue arrow), and intra-tubular hyaline casts (red arrows). E) GM divided-dose (120 mg/kg) group showing atrophied glomerulus (G) with wide Bowman’s space (BS), marked tubular necrosis (black arrow), and scattered viable proximal tubules (p) with apoptotic epithelial lining (blue arrow) and intra-tubular hyaline casts (yellow arrow). F) GM + MLK group showing normal glomeruli (G) with normal Bowman’s spaces (BS), mild tubular necrosis (black arrow), and proximal tubules (P) with mild apoptotic epithelial lining (blue arrow).