Table 2.
Univariate and multivariate analysis of factors associated with organ-specific and systemic autoimmunity in HT patients (n = 140).
| Characteristics | Systemic autoimmunity (n = 61) | Organ-specific autoimmunity (n = 79) | Univariate analysis (p value) | Multivariate analysis# (OR, 95% CI) |
|---|---|---|---|---|
| Mean age (years) | 55.20±13.9 | 48.72±12.5 | 0.005 | 0.954 (0.927-0.982), p = 0.002 |
| Gender (females) | 55 (90.2%) | 69 (87.3%) | 0.790 | 0.737 (0.229-2.374), p = 0.610 |
| APCA | 10 (16.4%) | 26 (32.9%) | 0.032 | 3.100 (1.256-7.652), p = 0.014 |
| TPO antibodies | 51 (83.6%) | 67 (84.8%) | 1.000 | 1.214 (0.422-3.490), p = 0.719 |
| Tg antibodies | 42/59 (71.2%) | 59/78 (75.6%) | 0.695 | 1.879 (0.776-4.552), p = 0.162 |
| Family history for thyroid autoimmunity | 32 (52.5%) | 50/77 (64.9%) | 0.164 | 1.723 (0.807-3.680), p = 0.160 |
| Malignancies | 5 (8.2%) | 5 (6.3%) | 0.747 | 1.110 (0.265-4.651), p = 0.886 |
#135 patients included due to missing values.
Nagelkerke R Square 0.184, Cox & Schnell R Square 0.137 for logistic regression analysis.
APCA, anti-parietal cell antibodies; TPO, thyroid peroxidase; Tg, thyroglobulin, OR, odds ratio; 95% CI, 95% confidence intervals. Bold values denote statistical significance at the p<0.05 level.