Table 3.
Univariate and multivariate analysis of factors associated with papillary thyroid carcinoma in HT patients (n = 840).
| Characteristics | With PTC (n = 29) | Without PTC (n = 811) | Univariate analysis (p value) | Multivariate analysis# (OR, 95% CI) |
|---|---|---|---|---|
| Age (years) | 47.9±17.0 | 50.2±14.5 | 0.414 | – |
| Age (≥40 vs <40 years) | 17 (58.6%) | 612 (75.5%) | 0.049 | 0.463 (0.202-1.062) |
| Gender (females) | 26 (89.7%) | 667 (82.2%) | 0.340 | 1.823 (0.530-6.276) |
| APCA | 9 (31.0%) | 171 (21.1%) | 0.246 | 1.906 (0.747-4.864) |
| TPO antibodies | 19/26 (73.1%) | 698/809 (86.3%) | 0.079 | 0.440 (0.164-1.178) |
| Tg antibodies | 23 (79.3%) | 555/795 (69.8%) | 0.309 | 1.214 (0.451-3.267) |
| Family history for thyroid autoimmunity | 21 (72.4%) | 440/806 (54.6%) | 0.086 | 2.808 (1.105-7.134) |
| Coexistence of other autoimmune diseases | 2 (6.9%) | 138 (17.0%) | 0.205 | 0.368 (0.085-1.592) |
#814 patients included due to missing values.
Nagelkerke R Square 0.079, Cox & Schnell R Square 0.019 for logistic regression analysis.
APCA, anti-parietal cell antibodies; TPO, thyroid peroxidase; Tg, thyroglobulin, PTC, papillary thyroid carcinoma; OR, odds ratio; 95% CI, 95% confidence intervals. Bold values denote statistical significance at the p<0.05 level.