TABLE 3.
Pharmacokinetic parameters of acyclovir following intravenous and oral administrationa
| Parameter | Intravenous acyclovir (n = 6)
|
Oral acyclovir (n = 7)
|
|||||
|---|---|---|---|---|---|---|---|
| CLt (liters/h/kg) | Vβ (liters/kg) | CLd (liters/h/kg) | t1/2 (h) | CL/F (liters/h/kg) | V/F (liters/kg) | t1/2 (h) | |
| Mean | 0.16 | 0.89 | 0.15 | 3.67 | 1.47 | 5.54 | 2.78 |
| SD | 0.03 | 0.59 | 0.12 | 1.85 | 0.47 | 2.43 | 1.38 |
| CV (%) | 20 | 67 | 79 | 50 | 32 | 44 | 49 |
a
CLt, total body clearance; CLd, distributional clearance between the central and peripheral compartments; Vβ, terminal distribution volume; t1/2, elimination half-life; CL/F, apparent clearance; V/F, apparent distribution volume; CV, coefficient of variation.