Table 4.
Lipid peroxidation products and enzymatic antioxidants activities in rats pretreated with AHALE and AHALE-ZnONPs followed by ISO exposure.
| Treatment | TBARS | LOOH | GPx | GRx | GST |
|---|---|---|---|---|---|
| Control | 1.72 ± 0.11 d | 27.15 ± 2.4 d | 6.21 ± 0.7 a | 8.73 ± 0.6 a | 792.53 ± 34.5 a |
| Isoproterenol | 8.41 ± 0.84 a | 69.42 ± 7.2 a | 2.47 ± 0.2c | 3.51 ± 0.1 d | 389.42 ± 27.3 e |
| AHALE50 + ISO | 7.63 ± 0.63 a,b | 63.12 ± 6.1 a,b | 2.68 ± 0.3c | 3.96 ± 0.2c,d | 402.31 ± 38.2 d,e |
| AHALE150 + ISO | 6.29 ± 0.52b | 57.91 ± 5.2b | 3.15 ± 0.4b,c | 4.59 ± 0.3c | 457.82 ± 41.7 d |
| AHALE300 + ISO | 4.88 ± 0.17c | 49.27 ± 4.3c | 4.52 ± 0.3b | 5.79 ± 0.2b,c | 525.60 ± 35.1c |
| AHALE-ZnONPs 50 + ISO | 6.83 ± 0.40b | 56.82 ± 3.3b | 3.19 ± 0.2b,c | 4.52 ± 0.1c | 435.52 ± 46.6 d |
| AHALE-ZnONPs 150 + ISO | 4.21 ± 0.35c | 48.72 ± 4.1c | 4.46 ± 0.5b | 5.38 ± 0.4b,c | 537.15 ± 29.4c |
| AHALE-ZnONPs 300 + ISO | 3.11 ± 0.14c | 35.65 ± 3.9 d | 5.37 ± 0.6 a,b | 6.51 ± 0.5b | 655.91 ± 44.2b |
TBARS (mmol/100 g wet tissue); LOOH (mmol/100 g wet tissue); GPx (µg of GSH oxidized/min/mg protein); GRx (nmol of NADPH oxidized/min/100 mg protein); GST (nmol of CDNB conjugated/min/mg protein); MI: Myocardial infarction AHALE: A. herba alba leaves extract; ZnONPs: Zinc Oxide nanoparticles; 50, 150, and 300: doses of AHALE or AHALE-ZnONPs; Data are presented as mean ± SEM. a,b,c,d,e Mean values within treatment with different superscript letters were significantly different (p < 0.05).