Table 4.
Histopathological scoring of lesions in the different organs of five birds/group (n = 5). The histopathological lesions were scored through the determination of the percentage of lesions in five randomly examined microscopic fields per bird (n = 5) as follows: (−) no lesions of 0–10%, (+) mild lesions of 10–20%, (++) moderate lesions of 20–60% and (+++) severe lesions of greater than 60%.
| Treatments |
Trachea |
Lungs |
Spleen |
Cecal tonsils |
Liver |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Edema in the lamina propria/submucosa | Infiltration of inflammatory cells | Activation of mucous-secreting glands | Congestion | Edema | Infiltration of inflammatory cells | Exudate in the parabronchus | Lymphocytic necrosis and depletion | Fibrinoid necrosis | Infiltration of heterophils | Lymphocytic necrosis and depletion | Congestion | Vacuolar degeneration of hepatocytes | Hepatocellular necrosis | |
| Group 1 (0.25 mg/kg) | + | + | − | ++ | − | + | − | − | − | − | + | + | − | − |
| Group 2 (0.5 mg/kg) | + | − | − | − | + | + | − | − | − | − | − | + | − | − |
| Group 3 (1 mg/kg) | − | − | − | − | + | − | − | − | − | − | − | + | − | − |
| Group 4 (0.02 mg /dose) | ++ | + | − | ++ | − | + | − | + | − | + | + | + | − | + |
| Group 5 (0.06 mg /dose) | ++ | + | − | + | + | − | − | − | − | − | + | − | + | − |
| Group 6 (0.1 mg /dose) | + | − | − | + | + | − | − | − | − | − | − | − | + | − |
| Group 7 (vac. Only) | ++ | + | + | ++ | + | + | − | ++ | − | + | + | + | + | − |
| Group 8 (H5N1) | ++ | ++ | +++ | +++ | +++ | ++ | ++ | +++ | ++ | ++ | +++ | ++ | +++ | + |