. 2019 Oct 14;9(56):32759–32770. doi: 10.1039/c9ra07299c

H/D exchange rate constants and half-lives of approximately 5 mM solution of molecules 1–4 in the solvent CDCl₃. The values were calculated using the integral area of NH peaks in the ¹H NMR spectrum of 10% CD₃OD/CDCl₃ samples.

Molecule	Substituent (X)	H/D exchange rate constant (k) (min⁻¹)	Half-life (t_1/2) (min)
1	F	6.4 × 10⁻³	108.28
2	Cl	7.46 × 10⁻³	92.89
3	OMe	4.82 × 10⁻³	143.77
4	H	8.19 × 10⁻³	84.61

H/D exchange rate constants and half-lives of approximately 5 mM solution of molecules 1–4 in the solvent CDCl3. The values were calculated using the integral area of NH peaks in the 1H NMR spectrum of 10% CD3OD/CDCl3 samples.