TABLE 3.
Allometric relationships for the PK parameters of GM 237354 across four species (mouse, rat, rabbit, and monkey)
| Parameter | Forecast value (95% CI) | Allometric equationa | r2 | P value |
|---|---|---|---|---|
| CLp (ml/min) | 1.5 (0.8–2.2) | log(CLp) = 0.78 + [0.66 · log(BW)] | 0.949 | 0.050 |
| t1/2 (h) | 8.9 (7.2–10.6) | log(t1/2) = 4.29 + [−2.54 · log(LBF)] | 0.940 | 0.059 |
| t1/2 (h) | log(t1/2) = −0.21 + [0.21.log(BW)] | 0.585 | 0.413 | |
| VSS (liters) | 0.2 (0.09–0.31) | log(VSS) = −0.49 + [0.87 · log(BW)] | 0.996 | 0.004 |
a
LBF values (in milliliters per minute per kilogram) used (6): mouse, 90; rat, 55; rabbit, 71; cynomolgus monkey, 44; human, 21.