Table 1.
Comparison of selected features of three unusual FFA subtypes.
| Atypical FFA pattern | Male pattern | Plaque pattern | Ophiasic pattern | p value |
Total | |||
|---|---|---|---|---|---|---|---|---|
| n = 12 (100.0%) | n = 7 (100.0%) | n = 8 (100.0%) | Male × Plaque | Male × Ophiasic | Plaque × Ophiasic | Overall | n = 27 (100%) | |
| Age: mean (SD) | 65.3 (7.3) | 60.7 (8.9)a | 64.4 (14.4) | 0.260 | 0.831 | 0.508 | 0.693 | 63.9 (10.0)b |
| Fitzpatrick II–III phototypec: n (%) | 6 (50.0) | 4 (57.1) | 1 (12.5) | 0.764 | 0.085 | 0.067 | 0.133 | 11 (40.7) |
| Approximate progression (cm/year): mean (SD) | 1.02 (1.07)d | 0.67 (0.51)e | 2.25 (1.22)f | 0.581 | 0.026i | 0.038i | 0.026i | 1.31 (1.18)g |
| Stability: n (%) | 8 (66.7) | 4 (57.1) | 1 (12.5) | 0.678 | 0.017i | 0.067 | 0.054 | 13 (48.1) |
| Disease duration until stabilization (months):mean (SD) | 27.0 (16.0)h | 18.8 (6.7)h | 36 (0)h | 0.503 | – | – | 0.474 | 25.2 (13.6)h |
| Disease evolution (years): mean (SD) | 6.7 (5.3) | 7.5 (6.4)a | 6.7 (3.4)a | 0.564 | 0.931 | 0.640 | 0.944 | 6.9 (5.0) |
| Facial papules: n (%) | 4 (33.3) | 0 (0.0) | 2 (25.0) | 0.086 | 0.690 | 0.155 | 0.284 | 6 (22.2) |
| Lichen planus pigmentosus: n (%) | 3 (25.0) | 0 (0.0) | 3 (37.5) | 0.149 | 0.550 | 0.070 | 0.240 | 6 (22.2) |
| Eyebrow alopecia: n (%) | 11 (91.7) | 0 (0.0) | 7 (87.5) | <0.001i | 0.761 | <0.001i | <0.001i | 18 (66.7) |
| Comorbidities: n (%) | ||||||||
| Systemic arterial hypertension | 6 (50.0) | 6 (85.7) | 6 (75.0) | 0.120 | 0.264 | 0.605 | 0.281 | 18 (66.7) |
| Diabetes mellitus | 2 (16.7) | 3 (42.9) | 3 (37.5) | 0.211 | 0.292 | 0.833 | 0.346 | 8 (29.6) |
| Dyslipidemia | 4 (33.3) | 2 (28.6) | 2 (25.0) | 0.830 | 0.690 | 0.876 | 0.935 | 8 (29.6) |
| Hypothyroidism | 3 (25.0) | 2 (28.6) | 1 (12.5) | 0.865 | 0.494 | 0.438 | 0.661 | 7 (25.9) |
Notes: 2 × 2 comparisons of continuous variables were carried out using Student's t test for independent samples; 3 × 2 comparisons of continuous variables used the Analysis of Variance (ANOVA) table; percentage comparisons used Fisher's exact test; SD, Standard Deviation.
a
n = 6.
b
n = 26.
c
in comparison with Fitzpatrick phototype IV–VI.
d
n = 11.
e
n = 5.
f
n = 7.
g
n = 15.
h
only for patients who reported stability; Stata 12.0/SE for Mac was used.
i
p < 0.05; the approximate progression for those without full follow-up was estimated as a direct proportion of the presumed one-year progression.