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A and B, A mixed-effects model for repeated measures was used to compare the difelikefalin (0.25, 0.5, and 1.0 μg/kg) and placebo groups. C, A comparison between the difelikefalin (0.25, 0.5, and 1.0 μg/kg) and placebo groups was performed using the Fisher exact test. Error bars indicate SEs. NRS indicates Numerical Rating Scale.
aP < .05.
