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. 2022 Apr 21;23(6):184. doi: 10.3892/ol.2022.13304

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Copyright: © Qi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — SIX1 is upregulated in NSCLC tissues and correlates with LDH level in patients with NSCLC. (A) mRNA levels of SIX1 in NSCLC tissues (n=30) and normal lung tissues (n=30) were detected by reverse transcription-quantitative PCR. **P<0.01 vs. normal lung tissue. (B) The protein levels of SIX1 in NSCLC tissues and normal lung tissues were detected by western blot analysis. (C) The overall survival of NSCLC patients with low or high levels of SIX1 was analyzed by Kaplan-Meier analysis of data from The Cancer Genome Atlas database (P=0.00319). (D) The correlation between mRNA expression level of SIX1 and serum LDH level in patients with NSCLC was analyzed by Pearson's correlation analysis (R=0.6796, P=0.0014). NSCLC, non-small cell lung cancer; SIX1, sine oculis homeobox homolog 1; T, tumor; N, normal; LDH, lactate dehydrogenase.