Table 5.
Determinants of quantitative serology response – Results of meta-analysis
| Characteristics* | Mean (SD) antibody level (ln(Ab)/SD) | RR (95% CI) |
|---|---|---|
| Sex [Bo, Bs, V] | ||
| Men | 6.57 (1.15) | 1 (Ref) |
| Women | 6.61 (1.10) | 1.08 (1.04-1.11) |
| Age [Bo, Bs, V] | ||
| 10-yr increase | - | 0.83 (0.78-0.88) |
| Job Title [Bo, Bs, V] | ||
| Administration | 6.33 (1.16) | 1 (Ref) |
| Physician | 6.64 (1.08) | 0.98 (0.87-1.09) |
| Nurse | 6.63 (1.13) | 0.98 (0.91-1.06) |
| Technician | 6.49 (1.09) | 1.03 (0.97-1.10) |
| Other HCW | 6.62 (1.12) | 0.98 (0.91-1.06) |
| Previous COVID-19 infection [Bo, Bs, V] | ||
| No | 6.39 (0.94) | 1 (Ref) |
| Yes | 7.89 (0.87) | 4.39 (4.24-4.54) |
| Time since vaccination [Bo, Bs] | ||
| 14-day interval | - | 0.97 (0.95-1.00) |
| Pre-vaccination serology level [Bs, V] | ||
| 1 SD increase | - | 1.19† (1.16-1.21) |
| Time between serology tests [Bs, V] | ||
| 30-day interval | - | 1.03† (1.02-1.05) |
CI, confidence interval; RR, meta-analytic relative risk for increase of 1 SD ln(Ab), adjusted for sex, age, job title and previous infection, as appropriate; Ref, reference category; † Additionally adjusted for pre-vaccination serology level and time between serology tests, as appropriate