TABLE 3.
Median (IQR) of hemostatic, endothelial, and inflammatory parameters, stratified by COVID‐19 severity and COVID‐19 vaccination
| COVID‐19 severity a , b | COVID‐19 vaccinated a | |||||
|---|---|---|---|---|---|---|
| Parameters | Asymptomatic mild/moderate (non‐oxygen dependent) | Severe/critical (oxygen dependent) | p value | No | Yes | p value |
| Fibrinogen (g/L) | 3.2 (2.8, 3.8) | 3.3 (2.7, 3.8) | .14 | 3.4 (2.7, 3.8) | 3.1 (2.7, 3.8) | .93 |
| D‐dimer (ug/mL) | 0.30 (0.28, 0.43) | 0.40 (0.36, 0.61) | .14 | 0.34 (0.31, 0.40) | 0.33 (0.28, 0.50) | .93 |
| FVIII (%) | 152 (116, 182) | 130 (122, 202) | .81 | 147.5 (101, 202) | 150 (120, 184) | .97 |
| FV (%) | 94 (81, 107) | 100.5 (91, 109) | .32 | 92 (75, 105) | 95 (85, 109) | .37 |
| vWFAg (%) | 111 (84, 142) | 120 (104, 197) | .31 | 118 (84, 218) | 111 (90, 148) | .73 |
| ICAM1 (ng/mL) | 51.8 (43.8, 56.8) | 63.0 (46.1, 75.9) | .16 | 51.2 (42.7, 63.6) | 54.4 (43.9, 65.0) | .60 |
| ETP (nM*min) (Thromboscreen without TM) | 1352 (1187, 1510) | 1294.5 (1137, 1434) | .44 | 1287 (1137, 1352) | 1394 (1170, 1510) | .19 |
| Peak height (nM) (Thromboscreen without TM) | 230.8 (187.7, 280.4) | 188.4 (116.4, 254.5) | .11 | 211.4 (177.1, 254.4) | 230.8 (170.2, 280.4) | .38 |
| Delayed lag time (min) (Thromboscreen without TM) | 2.43 (2.05, 2.63) | 2.64 (2.20, 2.94) | .20 | 2.13 (1.99, 2.33) | 2.45 (2.34, 2.75) | .054 |
a
There were no statistically significant differences in the laboratory parameters between the risk factors in comparison.
b
COVID‐19 severity defined by NIH Treatment Guidelines, clinical spectrum of SARS‐CoV‐2 infection (updated October 19, 2021) (Reference 12).