Time-kill studies. (A and B) P. aeruginosa PAO1 exposed to tobramycin (0.5 μg/ml), SMAP29 (2 μg/ml), or a combination of the two drugs. (A) Organisms after the first 8 h of exposure to each drug. (B) The organisms exposed to tobramycin and SMAP29 in combination were grown for 24 h and then rediluted and exposed to fresh tobramycin, SMAP29, or a combination of the two drugs (C) P. aeruginosa clinical strain 50BK exposed to tobramycin (1.0 μg/ml), SMAP29 (0.5 μg/ml), or SMAP29* (1.0 μg/ml).