FIG. 2.

Activity of SMAP29 against P. aeruginosa in CF sputum. The activities against strains of P. aeruginosa in CF sputum of tobramycin (250 μg/ml), SMAP29 (250 or 1,000 μg/ml), and a PBS control with no antibiotics were compared. CFU/ml were determined after 10, 60, 240, 300, and 480 min of exposure to antibiotics as shown. The effects of the addition of a second dose at 240 min of tobramycin (final concentration, 500 μg/ml) or SMAP29 (final concentration, 500 or 2,000 μg/ml) are also shown. The arrow indicates the timing of the addition of the second dose of antibiotics. The results are representative of three replicate studies.