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Example of chemical allostery. The 100 shortest allosteric pathways from the residues at the end of the Q arrows to the residues indicated by the Q′ arrow for the protein IGPS, adapted from Ref. 15. In IGPS, binding a ligand near the highlighted residues in the orange/left domain accelerates catalysis of a chemical reaction in the white/right domain at the highlighted region by ~5000 fold.15
