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. 2022 May 5;22:125. doi: 10.1186/s12906-022-03610-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — RWF extract inhibited proliferation in BPH-1 and WPMY-1 cells. a Morphological changes of BPH-1 and WPMY-1 cells under the treatment of RWF extract for 48 h. Scale bar, 100 μm. b, c The cytotoxic effects of RWF extract on cell viability by the MTT assay. RWF extract was used to treat BPH-1 and WPMY-1 cells at the indicated concentrations for 0, 24, 48, and 72 h. Data were presented as mean ± SD; *** p < 0.001 indicated a significant difference between cells treated with RWF extract at indicated concentrations and non-treated cells