Fig. 2.

Simplified depiction of model. Clinical pathways for strategies 4, 6 and 8 are the same as for strategies 3, 5 and 7, respectively, except that patients identified as low risk are screened biennially instead of no screening. Clinical pathways for progression to in situ or invasive cancer and to death follow the pathways described in Schousboe et al, 2011 [14]). Beyond age 50, in all strategies except strategies 1 and 2, women without family history undergo biennial screening; those with family history undergo annual screening