Table 1.
Expression and characteristic features of cancer-related circRNAs in the Wnt pathway
| Type | circRNA | Expression | Prognostic indicator | Clinical feature | Refs |
|---|---|---|---|---|---|
| Gastric cancer | circ0005654 | Upregulated | Overall survival | [159] | |
| Gastric cancer | circ_SMAD4 | Upregulated | Overall survival | [73] | |
| Gastric cancer | cir-ITCH | Downregulated | Overall survival | Lymph node metastasis | [160] |
| Gastric cancer | circHIPK3 | Upregulated | Overall survival | [161] | |
| Colorectal cancer | circRASSF2 | Upregulated | Overall survival | [162] | |
| Colorectal cancer | circ_0082182 | Upregulated | Overall survival | TNM stage | [163] |
| Colorectal cancer | circ-PRKDC | Upregulated | TNM grades, lymph node metastasis, tumor size, and 5-FU Resistance | [164] | |
| Colorectal cancer | circ5615 | Upregulated | Overall survival | T stage | [165] |
| Colorectal cancer | circCCT3 | Upregulated | Disease-free survival | Advanced stage | [166] |
| Colorectal cancer | circ _ 0005075 | Upregulated | Overall survival, and disease-free survival | Histology/differentiation, invasion depth, and TNM stage | [167] |
| Colorectal cancer | circMTO1 | Downregulated | Overall survival | Advanced TNM stage, and lymph node metastasis | [70] |
| Colorectal cancer | circRNA_100290 | Upregulated | Overall survival | Tumor metastasis | [168] |
| Liver cancer | circ_0004018 | Downregulated | Tumor size | [169] | |
| Liver cancer | circ_0003418 | Downregulated | Tumor size, TNM stage, and HBsAg level | [170] | |
| Liver cancer | circZKSCAN1 | Overall, and recurrence-free survival rate | [171] | ||
| Liver cancer | circZFR | Upregulated | Overall survival | [172] | |
| Liver cancer | circ_0067934 | Upregulated | Overall survival | TNM stage | [173] |
| Liver cancer | circ-ITCH | Downregulated | Overall survival | [174] | |
| Lung cancer | circ_000984 | Upregulated | Overall survival, and disease-free survival | TNM stage, and lymph nodes metastasis | [175] |
| Lung cancer | circ_001569 | Upregulated | Overall survival | Tumor differentiation, lymph node metastasis, and TNM stage | [176] |
| Lung cancer | circ_0001946 | Upregulated | Overall survival | TNM stage, and tumor size | [177] |
| Lung cancer | circ_0018414 | Downregulated | Overall survival | [178] | |
| Lung cancer | circ_0006427 | Downregulated | Overall survival | [179] | |
| Lung cancer | circ_0007059 | Downregulated | Different stages | [180] | |
| Lung cancer | cir-ITCH | Downregulated | Age | [181] | |
| Glioma | circ_0001730 | Upregulated | Clinical stage | [182] | |
| Glioma | circ_0000177 | Upregulated | Overall survival | [183] | |
| Ovarian cancer | circPLEKHM3 | Downregulated | Overall survival, and recurrence-free survival | [184] | |
| Endometrial carcinoma | circ_0109046 | Upregulated | 5-year survival | [185] | |
| Endometrial carcinoma | circ_0002577 | Upregulated | Overall survival rate | FIGO stage, and lymph node metastasis | [186] |
| Osteosarcoma | circ_0002052 | Downregulated | Overall survival, and progression-free survival | [187] | |
| Thyroid cancer | circ-ITCH | Downregulated | Clinical stage, and lymph node metastasis | [188] | |
| Breast cancer | circ-EIF6 | Upregulated | Overall survival | Histological grade, and distant metastasis | [189] |
| Breast cancer | circ-ITCH | Downregulated | Overall survival | [190] | |
| Breast cancer | circRNA_069718 | Upregulated | Overall survival | TNM stage, and lymph node metastasis | [191] |