Table 2.
The functions and mechanisms of Wnt-associated circRNAs in cancer
| Category | Type | circRNA | Role | Functions | Targeted molecule | Refs |
|---|---|---|---|---|---|---|
| Digestive tumors | Esophageal cancer | circRNA_100367 | Oncogene | EMT, proliferation, migration, and radioresistance | miR-217, and Wnt3 | [192] |
| Esophageal cancer | cir-ITCH | Tumor suppressor | Cell cycle, and cell proliferation | miRNA, Wnt | [193] | |
| Gastric cancer | circ0005654 | Oncogene | Proliferation, migration, and invasiveness | miR-363, SP1, Wnt, and β-catenin | [159] | |
| Gastric cancer | circRNA _ asap2 | Oncogene | Proliferation, migration, invasion, and cell apoptosis | Wnt, and β-catenin | [194] | |
| Gastric cancer | circ-SFMBT2 | Oncogene | Proliferation, migration, invasion, cell apoptosis, and oxidative stress | miR-885-3p, CHD7, Wnt, and β-catenin | [195] | |
| Gastric cancer | circCNIH4 | Tumor suppressor | Proliferation, migration, invasion, and cell apoptosis | DKK2. FRZB, Wnt, and β-catenin | [196] | |
| Gastric cancer | circ_SMAD4 | Oncogene | Proliferation, and cell apoptosis | miR-1276, CTNNB1, Wnt, and β-catenin | [73] | |
| Gastric cancer | circRNA_0044516 | Oncogene | Proliferation, and cell apoptosis | miR-149, Wnt1, and β-catenin | [197] | |
| Gastric cancer | cir-ITCH | Tumor suppressor | Cell proliferation, migration, and invasion | miR-17, Wnt, and β-catenin | [160] | |
| Gastric cancer | circ_0001649 | Tumor suppressor | Proliferation, migration, invasion, and cell apoptosis | miR-20a, ERK, and Wnt/β-catenin | [198] | |
| Gastric cancer | circHIPK3 | Oncogene | Proliferation, and migration | Wnt1, and β-catenin | [161] | |
| Colorectal cancer | circ_0038718 | Oncogene | Cell proliferation, migration, and invasion | miR-195-5p, Axin2, and Wnt/β-catenin | [199] | |
| Colorectal cancer | circ_0026628 | Oncogene | Cell proliferation, migration, and stemness | miR-346, FUS protein, SP1, Wnt/β-catenin, and Sox2 | [200] | |
| Colorectal tumor | cis-HOX | Oncogene | Self-renewal, tumorigenesis, and metastatic capacities of TICs | FZD3, Wnt/β-catenin, and KSRP | [201] | |
| Colorectal cancer | circRASSF2 | Oncogene | Cell proliferation, migration, invasion, and cell apoptosis | miR-195-5p, FZD4, Wnt, and β-catenin | [162] | |
| Colorectal cancer | circSMARCA5 | Tumor suppressor | Cell proliferation, migration, and invasion | miR-552, Wnt, and YAP1 | [202] | |
| Colorectal cancer | circ_0082182 | Oncogene | Cell proliferation, cell cycle, apoptosis, and metastasis | miR-411, miR-1205, and Wnt/β-catenin | [163] | |
| Colorectal cancer | circAGFG1 | Oncogene | Cell proliferation, migration, stemness, and apoptosis | mir-4262, miR-185-5p, YY1, CTNNB1, Wnt, and β-catenin | [203] | |
| Colorectal cancer | circ-PRKDC | oncogene | 5-FU resistance, cell proliferation, and invasion | FOXM1, miR-375, Wnt, and β-catenin | [164] | |
| Colorectal cancer | circ5615 | Oncogene | Cell proliferation, cell cycle, and invasion | miR-149-5p, TNKS, Wnt, and β-catenin | [165] | |
| Colorectal cancer | circ-ABCC1 | Oncogene | Cell stemness, sphere formation, and metastasis | Wnt | [204] | |
| Colorectal cancer | circCCT3 | Oncogene | Cell invasion, and apoptosis | miR-613, Wnt3, miR-613, and VEGFA | [166] | |
| Colorectal cancer | circ _ 0009361 | Tumor suppressor | Cell proliferation, migration, invasion, and EMT | miR-582, Wnt, and β-catenin | [205] | |
| Colorectal cancer | circ _ 0005075 | Oncogene | Cell proliferation, migration, and invasion | Wnt, and β-catenin | [167] | |
| Colorectal cancer | circMTO1 | Tumor suppressor | Cell proliferation, and invasion | Wnt, and β-catenin | [70] | |
| Colorectal cancer | circ _ 0000523 | Tumor suppressor | Cell proliferation, and apoptosis | miR-31, Wnt, and β-catenin | [206] | |
| Colorectal cancer | circRNA_100290 | Oncogene | Cell proliferation, migration, and invasion | miR-516b, FZD4, Wnt, and β-catenin | [168] | |
| Colorectal cancer | cir-ITCH | Tumor suppressor | Cell proliferation | Wnt, and β-catenin | [207] | |
| Liver cancer | circRNA-SORE | Oncogene | Sorafenib resistance, and apoptosis., | Wnt, and β-catenin | [71] | |
| Liver cancer | circ_0004018 | Tumor suppressor | Cell proliferation, and migration | miR-626, DKK3, Wnt, and β-catenin | [169] | |
| Liver cancer | circ-ITCH | Tumor suppressor | Cell proliferation, and apoptosis | Wnt, β-catenin, c-Myc, and CyclinD1 | [174, 208] | |
| Liver cancer | circ_0003418 | Tumor suppressor | Cell proliferation, migration, invasion, and cisplatin resistance | Wnt, and β-catenin | [170] | |
| Liver cancer | circZKSCAN1 | Tumor suppressor | Cell stemness | FMRP, CCAR1, and Wnt | [171] | |
| Liver cancer | cZNF292 | Oncogene | Cell proliferation, and cell cycle | Wnt, β-catenin, and SOX9 | [209] | |
| Liver cancer | circβ-catenin | Oncogene | Cell growth, cell cycle, migration, and invasion | Wnt, and β-catenin | [210] | |
| Liver cancer | circZFR | Oncogene | Cell proliferation and EMT | Wnt, and β-catenin | [172] | |
| Liver cancer | circ_0067934 | Oncogene | Cell proliferation, migration, invasion, and apoptosis | miR-1324, FZD5, and β-catenin | [173] | |
| Liver cancer | circ-ITCH | Tumor suppressor | [174] | |||
| Pancreatic cancer | circ_0030167 | Tumor suppressor | Cell invasion, migration, proliferation and stemness | miR-338-5p, Wip1, Wnt 8, and β-catenin | [211] | |
| Respiratory system tumors | Lung cancer | circ-PGC | Oncogene | Cell viability, colony formation, cell migration, invasion, and glycolysis metabolism | miR-532-3p, FOXR2, Wnt, and β-catenin | [212] |
| Lung cancer | circ-ZNF124 | Oncogene | Cell proliferation, invasion, apoptosis, and cycle arrest | miR-498, YES, Wnt, and β-catenin | [213] | |
| Lung cancer | circ-BIRC6 | Oncogene | Cell proliferation, migration and invasion, and apoptosis | miR-4491, Wnt2B, and β-catenin | [214] | |
| Lung cancer | circ_0067934 | Oncogene | Cell proliferation, migration, invasion, and apoptosis | miR-1182, Klf8, Wnt, and β-catenin | [215] | |
| Lung cancer | circ_000984 | Oncogene | Cell proliferation, migration, invasion, and EMT | Wnt, and β-catenin | [175] | |
| Lung cancer | circ_001569 | Oncogene | Cell proliferation | Wnt, and β-catenin | [176] | |
| Lung cancer | circ_0043256 | Oncogene | Cell proliferation, and apoptosis | miR-1252, ITCH, and Wnt | [216] | |
| Lung cancer | circ-SOX4 | Oncogene | Cell proliferation, invasion, and migration | miR-1270, PLAGL2, and Wnt | [69] | |
| Lung cancer | circ_0001946 | Oncogene | Cell proliferation | miR-135a-5p, SIRT1, Wnt, and β-catenin | [177] | |
| Lung cancer | circ_0018414 | Tumor suppressor | Cell proliferation, stemness, and apoptosis | miR-6807-3p, DKK1, Wnt, and β-catenin | [178] | |
| Lung cancer | circ_0006427 | Tumor suppressor | Cell proliferation, migration, and invasion | miR-6783-3p, DKK1, Wnt, and β-catenin | [179] | |
| Lung cancer | circ_0007059 | Tumor suppressor | Cell proliferation, apoptosis, and EMT | miR-378, Wnt, and β-catenin | [180] | |
| Lung cancer | cir-ITCH | Tumor suppressor | Cell proliferation | Wnt, and β-catenin | [181] | |
| Nervous system neoplasms | Glioma | circ_0001730 | Oncogene | Cell proliferation, and migration | Sp1, miR-326, Wnt7B, and β-catenin | [182] |
| Glioma | circKIF4A | Oncogene | Colony formation, migration, invasion, and apoptosis | miR-139-3p, Wnt, and β-catenin | [217] | |
| Glioma | circ_0000177 | Oncogene | Cell proliferation, and invasion | miR-638, FZD7, and Wnt | [183] | |
| Glioma | cZNF292 | Oncogene | Cell proliferation, cell cycle, and angiogenic potential | Wnt, and β-catenin | [218] | |
| Genitourinary tumors | Prostate cancer | cir-ITCH | Tumor suppressor | Cell viability, and invasion | miR-17, Wnt, β-Catenin, PI3K, AKT, and mTOR | [219] |
| Ovarian cancer | circABCB10 | Oncogene | Cell proliferation, invasion, and cell apoptosis | miR-1271, Capn4, Wnt, and βcatenin | [220] | |
| Ovarian cancer | circPLEKHM3 | Tumor suppressor | Cell growth, and migration | miR-9, BRCA1, DNAJB6, KLF4, Akt1, Wnt, and β-catenin | [184] | |
| Endometrial carcinoma | circ_0109046 | Oncogene | Cell proliferation, aggressiveness, and apoptosis | miR105, SOX9, Wnt, and β-catenin | [185] | |
| Endometrial carcinoma | circ_0002577 | Oncogene | Cell proliferation, migration, and invasion | miR-197, CTNND1, Wnt, and β-catenin | [186] | |
| Cervical cancer | circSAMD11 | Oncogene | Cell proliferation, migration, invasion, and apoptosis | miR-503, SOX4, Wnt, and β-catenin | [221] | |
| Blood system cancers | Acute myeloid leukemia | circ_0121582 | Tumor suppressor | Cell proliferation, and cell cycle | miR-224, GSK3β, Wnt, and β-catenin | [222] |
| Chronic lymphocytic leukemia | circ-CBFB | Oncogene | Cell proliferation, cell cycle, and apoptosis | miR-607, FZD3, Wnt, and β-catenin | [223] | |
| Diffuse large B-cell lymphoma | circ-APC | Tumor suppressor | Cell viability, and cell cycle | Wnt, β-catenin, TET1, and miR-888 | [224] | |
| Musculoskeletal system tumors | Osteosarcoma | circUBAP2 | Oncogene | Cell proliferation, migration, invasion, apoptosis, and cisplatin resistance | miR-506-3p, SEMA6D, Wnt, and β-catenin | [225] |
| Osteosarcoma | circMYO10 | Oncogene | Cell proliferation, and emt | miR-370-3p, RUVBL1, Wnt, and β-catenin | [63] | |
| Osteosarcoma | circ_0002052 | Tumor suppressor | Cell proliferation, migration, invasion, and apoptosis | miR1205, APC2, Wnt, and β-catenin | [187] | |
| Endocrine system tumors | Thyroid cancer | circRNA_102171 | Oncogene | Cell proliferation, migration, invasion, and apoptosis. | CTNNBIP1, β-catenin, TCF3, TCF4, LEF1 complex, Wnt, and β-catenin | [226] |
| Thyroid cancer | circRNA_NEK6 | Oncogene | Cell growth, and invasion | FZD8, Wnt, and miR-370-3p | [227] | |
| Thyroid cancer | circ-ITCH | Tumor suppressor | Cell proliferation, invasion, and apoptosis | miR-22-3p, CBL, and β-catenin | [188] | |
| Other systems tumors | Breast cancer | circ-EIF6 | Oncogene | Cell proliferation, migration, and invasion | MYH9, Wnt, β-catenin, and EIF6-224aa | [189] |
| Breast cancer | circARL8B | Oncogene | Cell viability, migration, invasion, and fatty acid metabolism | miR-653-5p, PGE2, PI3K, AKT, GSK-3β, Wnt, and β-catenin | [228] | |
| Breast cancer | circABCC4 | Oncogene | Cell viability, migration, invasion, and apoptosis | miR-154-5p, NF-κB, Wnt, and β-catenin | [229] | |
| Breast cancer | circ-ITCH | Tumor suppressor | Cell proliferation, invasion, and metastasis | miR-214, miR-17, ITCH, Wnt, and β-catenin | [190] | |
| Breast cancer | circRNA_069718 | Oncogene | Cell proliferation, and invasion | Wnt, and β-catenin | [191] | |
| Breast cancer | circFAT1 | Oncogene | Cell apoptosis, migration, invasion, and oxaliplatin resistance | miR-525-5p, SKA1, Notch, and Wnt | [230] | |
| Melanoma | circ_0119872 | Oncogene | Cell proliferation, and angiogenesis | miR-622, G3BP1, Wnt, β-catenin, and mTOR | [231] | |
| Melanoma | circ-GLI1 (circ_0027247) | Oncogene | Cell metastasis, and angiogenesis | p70S6K2, Hedgehog, GLI1, Cyr61, Wnt, and β-catenin | [232] | |
| Melanoma | circ_0084043 | Oncogene | Cell proliferation, migration, invasion, and apoptosis | miR-429, and homolog 2, Wnt, and β-catenin | [233] |