Table 2.
Intervention and state costs and utilities used in the Markov model
| State costs | LARC | SE | LRRC | SE | Distribution | Source |
| Disease-free | € 492 | € 63 | € 492 | € 63 | Gamma | Expert |
| Transition from DF to PD | € 14.883 | € 1.898 | € 13.107 | € 1.672 | Gamma | Expert |
| Progressive disease | € 585 | € 75 | € 585 | € 75 | Gamma | Expert |
| Intervention costs | Combined LARC & LRRC | SE | Distribution | Source | ||
| Surgery | €10.970 | €1.399 | Gamma | [21] | ||
| Addition of navigation | €3.388 | €432 | Gamma | Expert | ||
| Developing 3D model and preoperative CT scan | € 269 | [22–24] | ||||
| Additional personnel during OR | € 197 | [22, 24] | ||||
| Navigation system | € 2.745 | List prices; expert | ||||
| Overhead | € 177 | [22] | ||||
| Utilities | Combined LARC & LRRC | SE | Distribution | Source | ||
| First cycle | 0.70 (n = 63) | 0.029 | Beta | [C] (1mo survey) | ||
| Disease free (subsequent cycles) | 0.85 (n = 44) | 0.022 | Beta | [C] (6mo survey) | ||
| Progressive disease (subsequent cycles) | 0.77 (n = 14) | 0.050 | Beta | [C] (6mo survey) | ||
SE Standard error, mo month, [C] Prospective observational cohort study