TABLE 2.
MICs of comparator quinolones for BMS-284756-selected mutants
| Strain group and IDa | MIC (μg/ml) of:
|
|||
|---|---|---|---|---|
| BMS-284756 | Ciprofloxacin | Levofloxacin | Moxifloxacin | |
| R6 parent | 0.015 | 0.5 | 0.5 | 0.125 |
| 1st level—A | 0.125 | 1 | 1 | 0.25 |
| 1st level—B | 0.06 | 1 | 1 | 0.25 |
| 1st level—C | 0.06 | 1 | 1 | 0.25 |
| 2nd level—A | 0.25 | 16 | 16 | 4 |
| 2nd level—B | 0.25 | 16 | 16 | 4 |
| 2nd level—C | 0.25 | 16 | 16 | 4 |
| 3rd level—A | 2 | 16 | 16 | 8 |
| 3rd level—B | 2 | 16 | 16 | 4 |
| 3rd level—C | 2 | 16 | 16 | 4 |
| 4th level—A | 16 | 32 | 64 | 64 |
| 4th level—B | 8 | 16 | 64 | 64 |
| 4th level—C | 16 | 16 | 64 | 64 |
a
ID, identification. Strains were derived from S. pneumoniae R6 as described in Materials and Methods. Each level of increasing strain resistance is derived from the preceding level of lower resistance by selection with BMS-284756. At least three independent mutants (designated A, B, and C) at each level were selected and subjected to MIC testing.