TABLE 4.
Changes in the QRDR of GyrA and ParC in BMS-284756-selected resistance mutantsa
| Strain or mutant group | Mutations in:
|
|
|---|---|---|
| GyrAb | ParCc | |
| R6 parent | S81, E85 | S79, D83 |
| 1st level resistant | S81F, E85 S81Y, E85 | S79, D83 |
| 2nd level resistant | S81Y, E85 | S79F, D85 |
| 3rd level resistant | S81Y, E85K S81Y, E85G | S79F, D85 |
| 4th level resistant | S81Y, E85K | S79F, D85G |
a
No changes were observed in GyrB or ParE in the present set of mutants.
b
Amino acid position and mutations of key amino acids in the QRDR of the GyrA protein, as derived from DNA sequences at each resistance level. Amino acid changes were determined for each of three independent isolates, and where variants among the mutants were present, both changes at that level are shown.
c
Amino acid positions and mutations of the QRDR of the ParC protein, as derived from DNA sequence at each resistance level. Amino acid changes were determined for each of three independent isolates.