Histopathological evaluation of collagen and fibroblast regeneration activitya.
| Name of sample | Fibroblast | Collagen | Regeneration | Comments |
|---|---|---|---|---|
| 9th day (control group) | — | — | — | Normal |
| 9th day (CAM) | + | + | + | Presence of collagen and fibroblast regeneration |
| 9th day (uncapped-CAM) | — | + | + | Skin tissue shows dense inflammation and minimal regeneration of collagen is present |
| 9th day (TSC-CAM) | ++ | + | + | Fibroblast regeneration |
| 9th day (PVP-CAM) | +++ | + | + | Fibroblast and collagen regeneration found to be satisfactory |
| 9th day (PVA-CAM) | +++ | ++ | ++ | Fibroblast are plentiful, but minimal inflammation is present |
| 9th day (SBD-CAM) | + | ++ | + | Skin ulceration shows dense inflammation, granulation tissue present |
| 14th day (control group) | + | + | + | Fibroblasts are present with collagen, inflammation is present |
| 14th day (CAM) | ++ | ++ | + | Presence of collagen fibers, fibrins, and erythrocytes regeneration |
| 14th day (uncapped-CAM) | + | ++ | + | Presence of minimal collagen with regeneration |
| 14th day (TSC-CAM) | ++ | + | + | Moderate regeneration |
| 14th day (PVP-CAM) | +++ | ++ | ++ | Maximum collagen and fibroblast with moderate regeneration |
| 14th day (PVA-CAM) | +++ | +++ | +++ | Equally maximum regeneration |
| 14th day (SBD-CAM) | + | ++ | ++ | Dense fibrosin and scant inflammation |
a
+ Represents minimum regeneration; ++ represents moderate regeneration; +++ represents maximum regeneration.