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. Author manuscript; available in PMC: 2022 May 6.
Published in final edited form as: Am J Transplant. 2020 Aug 9;21(4):1477–1492. doi: 10.1111/ajt.16174

FIGURE 2.

FIGURE 2

A, Clarke score. The Wilcoxon signed rank Test for paired outcomes was used to compare the median Clarke Survey score between baseline (N = 24) and day 365, day 730, and day 1095 following initial purified human pancreatic islets (PHPI) product transplant. The Benjamini-Hochberg (BH) method was used to adjust the level of significance in order to preserve the overall false discovery rate of 10%. The upper BH boundary was 0.0794 and the P values for the 2-sided Wilcoxon signed rank tests were P < .0001 for day 365, P = .0001 for day 730, and P = .0001 for day 1095. B, hypoglycemia (HYPO) score. The Wilcoxon signed rank test for paired outcomes was used to compare changes in median HYPO score between baseline and day 365 following initial PHPI product transplant. BH method was used to adjust the level of significance to preserve the overall false discovery rate of 10%. The upper BH boundary was 0.0794 and the P value for the 2-sided Wilcoxon signed rank test was .0078. Note: HYPO score results were only collected through day 365. C, Lability index (LI). The Wilcoxon signed rank test for paired outcomes was used to compare the changes in median LI scores between baseline and day 365 following initial PHPI product transplant. The BH method was used to adjust the level of significance to preserve the overall false discovery rate of 10%. The upper BH boundary was 0.0794 and the P value for the 2-sided Wilcoxon signed rank test was .0078. Note: LI results were only collected through day 365. D, Mean amplitude of glycemic excursions (MAGE) score. The Wilcoxon signed rank test for paired outcomes was used to compare changes in MAGE score between baseline and day 365 following initial PHPI product transplant. The BH method was used to adjust the level of significance to preserve the overall false discovery rate of 10%. The upper BH boundary was 0.0794 and the P value for the 2-sided Wilcoxon signed rank test was .0020. Note: MAGE score results were only collected through day 365