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. Author manuscript; available in PMC: 2022 May 6.
Published in final edited form as: Am J Transplant. 2020 Aug 9;21(4):1477–1492. doi: 10.1111/ajt.16174

FIGURE 5.

FIGURE 5

A, Diabetes Distress Scale (DDS) scores. The Wilcoxon signed rank test for paired outcomes was used to compare DDS from baseline and day 75, day 365, day 730, and day 1095 following initial purified human pancreatic islets (PHPI) product transplant. The Benjamini-Hochberg (BH) method was used to adjust the level of significance to preserve the overall false discovery rate (FDR) of 10%. The upper BH boundary was 0.0229 and the P values for the 2-sided Wilcoxon signed rank test were, respectively, P = .0020, P = .0062, P = .0195 and P = .0078. B, Overall Hypoglycemia Fear Survey (HFS) scores. The Wilcoxon signed rank test for paired outcomes was used to compare HFS from baseline to day 75, day 365, day 730, and day 1095 following initial PHPI product transplant. The BH method was used to adjust the level of significance to preserve the overall FDR of 10%. The upper BH boundary was 0.0229 and the P values for the 2-sided Wilcoxon signed rank test were, respectively, P = .0005, P = .0024, P = .0391, and P = .0469. C, Hypoglycemia Fear Survey (HFS) score as a function of insulin independence. The sample sizes are recorded as (nd = number of insulin dependent, ni = number of insulin independent) at day 75, day 365, day 730, and day 1095 following initial PHPI product transplantation. The BH method was used to adjust the level of significance to preserve the overall FDR of 10%. The upper BH boundary was 0.0229. Pairwise Wilcoxon P values comparing HFS scores among those who met insulin independence vs those who did not for day 75, day 365, day 730, and day 1095 were, respectively, P = .7250, P = .0783, P = .0171 and P = 1.0. D, Overall visual analog scale (VAS) Scores. The Wilcoxon signed rank test for paired outcomes was used to compare EuroQOL VAS from baseline to day 75, day 365, day 730, and day 1095 following initial PHPI product transplant. The BH method was used to adjust the level of significance to preserve the overall FDR of 10%. The upper BH boundary was 0.0229 and the P values for the 2-sided Wilcoxon signed rank test were, respectively, P = .1061, P = .0002, P = .0952 and P = .0327