Fig. 1. Biosynthetic gene clusters involved in the biosynthesis of various PKS-NRPS-derived compounds. Open reading frames are represented by arrows which are not to scale. Abbreviations: ER, enoyl reductase; KS, ketosynthase; AT, acyl transferase; DH, dehydratase; C-MeT, C-methyl transferase; ER⁰, non-functional ER; KR, ketoreductase; ACP, acyl carrier protein; C, condensation; A, adenylation; T, thiolation; R, reductive release; DKC, Dieckmann cyclase; pDA, putative Diels Alderase.