Figure 6.
Diabetes-induced visual dysfunction was absent in mice with Müller cell–specific REDD1 deletion. Diabetes was induced in REDD1fl/fl and REDD1-mgKO mice by administration of STZ. Control mice received a vehicle (Veh). All analysis was performed after 6 weeks of diabetes. Behavioral optometry was performed by displaying rotating bars on inward-facing monitors to elicit an optomotor reflex. Thresholds were averaged over three trials on consecutive days. A: SF was assessed at 100% contrast. B: CS was assessed at a spatial frequency of 0.092 cycles (c)/degree (d). CS is expressed as an inverse percentage to make data interpretation more intuitive. Bars are means ± SD (n = 8). *P ≤ 0.05 vs. Veh; #P ≤ 0.05 vs. REDD1fl/fl.