Table 3.

Nodes with significant altered local efficiency based on morphology covariance networks constructed from the Destrieux Atlas (n = 148)^*

Node	Patients with first-episode MDD n = 76	Healthy controls n = 66	p value
Thickness-based network
Left posterior-ventral part of the cingulate gyrus
Original	0.05	0.77	0.004
Random-null	0.83 ± 0.21	0.83 ± 0.21
Left triangular part of the inferior frontal gyrus
Original	0.87	0.75	0.005
Random-null	1.00 ± 0.03	1.00 ± 0.03
Left superior frontal sulcus†
Original	0.87	0.75	0.003
Random-null	1.02 ± 0.03	1.02 ± 0.03
Right paracentral lobule and sulcus†
Original	0.91	0.79	0.005
Random-null	1.06 ± 0.03	1.06 ± 0.03
Right posterior-ventral part of the cingulate gyrus
Original	0.11	0.78	0.002
Random-null	0.92 ± 0.16	0.92 ± 0.17
Right central sulcus
Original	0.92	0.77	0.001
Random-null	1.06 ± 0.04	1.05 ± 0.04
Surface area–based network
Left marginal part of the cingulate sulcus
Original	16.64	21.30	0.003‡
Random-null	20.57 ± 0.94	20.57 ± 0.91
Gyrification-based network
NA

MDD = major depressive disorder; NA = not applicable.

^*Brain nodes with significant altered local efficiency are presented separately by network. Values are mean ± standard deviation.

^†Showed a significant difference in local efficiency in both the Destrieux and Desikan–Killiany atlases.

^‡p < 1/148 or 0.0067.