TABLE 1.
Binding properties of tau PET tracers.
| Tracers | Affinity [nM] | Binding to AD (3R + 4R)/ PSP (4R)/ CBD (4R) | In silico binding site (S1 – S4) | References |
| 1st generation | ||||
| [18F]THK5317 | AD | Okamura et al., 2013 | ||
| [11C]THK5351 | 2.9 (AD) | AD PSP CBD |
1–4 Most strongly S1 and S3 | Harada et al., 2016; Betthauser et al., 2017 |
| [11C]PBB3 | 2.5, 6.3 (AD) 4.8 (PSP) | AD PSP CBD |
1–4 Most strongly S4 | Maruyama et al., 2013; Ono et al., 2017 |
| [18F]AV1451 | 14.6, 0.7 | AD | 1–4 Most strongly S1 | Chien et al., 2013; Xia et al., 2013 |
| 2nd generation | ||||
| [18F]RO948 | 18.5 | AD | 1–4 | Honer et al., 2018; Yap et al., 2021 |
| [18F]MK6240 | 0.32, 0.15, 0.3 | AD | 1–4 Most strongly S1 | Walji et al., 2016; Malarte et al., 2021; Yap et al., 2021 |
| [18F]PI-2620 | 4.9, 1.8 (AD) | AD PSP CBD |
Mueller et al., 2017; Kroth et al., 2021; Tezuka et al., 2021 | |
| [18F]JNJ311 | 8 | AD | 1–4 | Declercq et al., 2017 |
| [18F]PM-PBB3 | 7.63 (AD) 3.44 (PSP) | AD PSP CBD |
Tagai et al., 2021 | |
| [18F]GTP1 | 14.9 | AD | Lois et al., 2019; Teng et al., 2019 | |