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. 2021 Dec 17;28(5):667–679. doi: 10.1093/ibd/izab292

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© 2021 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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FIGURE 1. — Characterization of induced pluripotent stem cell (iPSC)–derived human intestinal organoids (HIOs) and purified mesenchymal cell population. A, Representative images showing iPSC-derived HIOs immunopositive for E-cadherin (E-cad) (red) and vimentin (Vim) (green), and all counterstained with DAPI (blue). Scale bar=50 μm. B, Representative dot plot showing populations of EpCAM+ and vimentin+ cells in HIOs derived from each iPSC line. C, Graph showing cellular populations in HIOs from 4-6 directed differentiations of each individual’s iPSC line. D, Representative dot plot of purified populations of iPSC-derived mesenchymal cells. VEOIBD, very early onset inflammatory bowel disease.